Narcotics investigates all narcotics complaints received from citizens; narcotic unit proactively investigates, infiltrates, and arrest narcotic traffickers and those involved in narcotic trafficking organizations, and drug labs; narcotic detectives frequently interact with district and other division deputies, providing assistance in street level narcotic enforcement in Guilford County regarding narcotics complaints, and law enforcement agencies at every level.

Vice proactively investigates any and all complaints regarding illicit vice and related conditions throughout the county; detectives employ the use of all-available technological resources and traditional investigative methods to preserve the quality of life in Guilford County.